Pub. Date : 2005 Apr
PMID : 15782327
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metal components analysis of metallothionein-III in the brain sections of metallothionein-I and metallothionein-II null mice exposed to mercury vapor with HPLC/ICP-MS. Mercury vapor is effectively absorbed via inhalation and easily passes through the blood-brain barrier; therefore, mercury poisoning with primarily central nervous system symptoms occurs. | Mercury | metallothionein 1 | Mus musculus |
| 2 | The mercury accumulated in brains after mercury vapor exposure for MT-I, II null mice and wild-type mice. | Mercury | metallothionein 1 | Mus musculus |
| 3 | The mercury levels of MT-I, II null mice in each brain section were significantly higher than those of wild-type mice after mercury vapor exposure. | Mercury | metallothionein 1 | Mus musculus |
| 4 | The mercury levels of MT-I, II null mice in each brain section were significantly higher than those of wild-type mice after mercury vapor exposure. | Mercury | metallothionein 1 | Mus musculus |
| 5 | A significant change of zinc concentrations with the following mercury vapor exposure for MT-I, II null mice was observed only in the cerebellum analyzed by two-way analysis of variance. | Mercury | metallothionein 1 | Mus musculus |
| 6 | Metal components of metal-binding proteins of soluble fractions in the brain sections were analyzed by size-exclusion high-performance liquid chromatography (HPLC) connected with ICP-MS. From the results of HPLC/ICP-MS analyses, it was concluded that the mercury components of MT-III and high molecular weight metal-binding proteins in the cerebellum of MT-I, II null mice were much higher than those of wild-type mice. | Mercury | metallothionein 1 | Mus musculus |
| 7 | It was suggested that MT-III is associated with the storage of mercury in conditions lacking MT-I, and MT-II. | Mercury | metallothionein 1 | Mus musculus |
| 8 | It was also suggested that the physiological role of MT-III and some kind of high molecular weight proteins might be impaired by exposure to mercury vapor and lack of MT-I and MT-II. | Mercury | metallothionein 1 | Mus musculus |