Title : Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints.

Pub. Date : 2005 May 26

PMID : 15782134






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The Chk1 inhibitor, 7-hydroxystaurosporine (UCN-01), overcomes both S and G(2) arrest preferentially in cells mutated for p53, driving cells through a lethal mitosis and thereby enhancing cytotoxicity. 7-hydroxystaurosporine tumor protein p53 Homo sapiens