Pub. Date : 2005 Jun 2
PMID : 15782121
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, we show that Hsp90 inhibits hydrogen peroxide (H(2)O(2))-induced ASK1-p38 activation in endothelial cells (EC). | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 2 | In the present study, we show that Hsp90 inhibits hydrogen peroxide (H(2)O(2))-induced ASK1-p38 activation in endothelial cells (EC). | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 3 | However, Akt is released from the N-terminal domain concomitant with binding to the C-terminal domain of ASK1 in response to ASK1 activator H(2)O(2), inhibitor of Hsp90 17-AAG and Akt inhibitor LY294002, leading to a more stable Hsp90-Akt-ASK1 complex. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 4 | However, Akt is released from the N-terminal domain concomitant with binding to the C-terminal domain of ASK1 in response to ASK1 activator H(2)O(2), inhibitor of Hsp90 17-AAG and Akt inhibitor LY294002, leading to a more stable Hsp90-Akt-ASK1 complex. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |
| 5 | However, Akt is released from the N-terminal domain concomitant with binding to the C-terminal domain of ASK1 in response to ASK1 activator H(2)O(2), inhibitor of Hsp90 17-AAG and Akt inhibitor LY294002, leading to a more stable Hsp90-Akt-ASK1 complex. | Hydrogen Peroxide | mitogen-activated protein kinase kinase kinase 5 | Homo sapiens |