Pub. Date : 2005 Apr 4
PMID : 15781218
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The EM9 cells that lack functional XRCC1 proteins exhibit severe sensitivity to methyl methanesulfonate (MMS). | Methyl Methanesulfonate | X-ray repair cross complementing 1 | Homo sapiens |
| 2 | The EM9 cells that lack functional XRCC1 proteins exhibit severe sensitivity to methyl methanesulfonate (MMS). | Methyl Methanesulfonate | X-ray repair cross complementing 1 | Homo sapiens |
| 3 | Introduction of the human XRCC1(WT) and XRCC1(R194W) gene to EM9 cells restored the MMS sensitivity to the same level as the AA8 cells, a parental cell line. | Methyl Methanesulfonate | X-ray repair cross complementing 1 | Homo sapiens |
| 4 | Introduction of the human XRCC1(WT) and XRCC1(R194W) gene to EM9 cells restored the MMS sensitivity to the same level as the AA8 cells, a parental cell line. | Methyl Methanesulfonate | X-ray repair cross complementing 1 | Homo sapiens |
| 5 | However, introduction of the XRCC1(R280H) gene partially restored the MMS sensitivity, resulting in a 1.7- to 1.9-fold higher sensitivity to MMS compared with XRCC1(WT) and XRCC1(R194W) cells at the LD(50) value. | Methyl Methanesulfonate | X-ray repair cross complementing 1 | Homo sapiens |
| 6 | However, introduction of the XRCC1(R280H) gene partially restored the MMS sensitivity, resulting in a 1.7- to 1.9-fold higher sensitivity to MMS compared with XRCC1(WT) and XRCC1(R194W) cells at the LD(50) value. | Methyl Methanesulfonate | X-ray repair cross complementing 1 | Homo sapiens |
| 7 | In addition, the amount of intracellular NAD(P)H decreased in XRCC1(R280H) cells after MMS treatment. | Methyl Methanesulfonate | X-ray repair cross complementing 1 | Homo sapiens |
| 8 | Indirect immunofluorescence staining of the XRCC1 protein showed an intense increase in the signals and clear foci of XRCC1 in the nuclei of the XRCC1(WT) cells, but a faint increase in the XRCC1(R280H) cells, after MMS exposure. | Methyl Methanesulfonate | X-ray repair cross complementing 1 | Homo sapiens |