Pub. Date : 2005 Jun
PMID : 15772291
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previous studies have indicated that CPT-11 can inhibit acetylcholinesterase (AChE), and here, we provide a detailed analysis of the inhibition of AChE by CPT-11 and by structural analogs. | Irinotecan | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Previous studies have indicated that CPT-11 can inhibit acetylcholinesterase (AChE), and here, we provide a detailed analysis of the inhibition of AChE by CPT-11 and by structural analogs. | Irinotecan | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | Previous studies have indicated that CPT-11 can inhibit acetylcholinesterase (AChE), and here, we provide a detailed analysis of the inhibition of AChE by CPT-11 and by structural analogs. | Irinotecan | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | These studies demonstrate that the terminal dipiperidino moiety in CPT-11 plays a major role in enzyme inhibition, and this has been confirmed by X-ray crystallographic studies of a complex of the drug with Torpedo californica AChE. | Irinotecan | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 5 | The 3D structure of the CPT-11/AChE complex also permits modeling of CPT-11 complexed with mammalian butyrylcholinesterase and carboxylesterase, both of which are known to hydrolyze the drug to the active metabolite. | Irinotecan | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 6 | The 3D structure of the CPT-11/AChE complex also permits modeling of CPT-11 complexed with mammalian butyrylcholinesterase and carboxylesterase, both of which are known to hydrolyze the drug to the active metabolite. | Irinotecan | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 7 | Overall, the results presented here clarify the mechanism of AChE inhibition by CPT-11 and detail the interaction of the drug with the protein. | Irinotecan | acetylcholinesterase (Cartwright blood group) | Homo sapiens |