Pub. Date : 2005 Apr
PMID : 15771957
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Depsipeptide (FR901228) enhances the cytotoxic activity of TRAIL by redistributing TRAIL receptor to membrane lipid rafts. | Depsipeptides | TNF superfamily member 10 | Homo sapiens |
| 2 | Depsipeptide (FR901228) enhances the cytotoxic activity of TRAIL by redistributing TRAIL receptor to membrane lipid rafts. | Depsipeptides | TNF superfamily member 10 | Homo sapiens |
| 3 | Thus, studies were initiated to evaluate the ability of depsipeptide to enhance the cytotoxic activity of Ad5-TRAIL against human prostate tumor cells. | Depsipeptides | TNF superfamily member 10 | Homo sapiens |
| 4 | Additionally, tumor cell killing by Ad5-TRAIL was higher following depsipeptide pretreatment. | Depsipeptides | TNF superfamily member 10 | Homo sapiens |
| 5 | Investigation into the mechanism responsible for increased TRAIL responsiveness revealed increased levels of TRAIL-R1 and -R2 in membrane lipid rafts following depsipeptide treatment. | Depsipeptides | TNF superfamily member 10 | Homo sapiens |
| 6 | These results indicate that depsipeptide is a potent agent for enhancing the activity of Ad5-TRAIL by multiple mechanisms, allowing for a more efficient use of Ad5-TRAIL as an antitumor therapy. | Depsipeptides | TNF superfamily member 10 | Homo sapiens |
| 7 | These results indicate that depsipeptide is a potent agent for enhancing the activity of Ad5-TRAIL by multiple mechanisms, allowing for a more efficient use of Ad5-TRAIL as an antitumor therapy. | Depsipeptides | TNF superfamily member 10 | Homo sapiens |