Pub. Date : 2005 Mar 11
PMID : 15766528
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Sustained JNK activation in NF-kappaB-deficient cells was suggested to depend on reactive oxygen species (ROS), but how ROS affect JNK activation was unclear. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | Sustained JNK activation in NF-kappaB-deficient cells was suggested to depend on reactive oxygen species (ROS), but how ROS affect JNK activation was unclear. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | We now show that TNFalpha-induced ROS, whose accumulation is suppressed by mitochondrial superoxide dismutase, cause oxidation and inhibition of JNK-inactivating phosphatases by converting their catalytic cysteine to sulfenic acid. | Reactive Oxygen Species | mitogen-activated protein kinase 8 | Homo sapiens |