Pub. Date : 2005 Mar 4
PMID : 15750390
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children. | Nelfinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | This research examined the impact of single nucleotide polymorphisms (SNP) of MDR1 and CYP genes on nelfinavir and efavirenz pharmacokinetics and the response to highly active antiretroviral therapy (HAART) in HIV-1 infected children. | Nelfinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | CONCLUSIONS: HIV-1 infected children with the MDR1-3435-C/T genotype had more rapid virologic responses to HAART at week 8 with higher plasma nelfinavir concentrations compared to those with the C/C genotype. | Nelfinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | These findings suggest that P-gp may play an important role in the pharmacokinetics and virologic response to HAART containing nelfinavir. | Nelfinavir | ATP binding cassette subfamily B member 1 | Homo sapiens |