Title : Cytotoxicity of RH1: NAD(P)H:quinone acceptor oxidoreductase (NQO1)-independent oxidative stress and apoptosis induction.

Pub. Date : 2005 Apr

PMID : 15746574






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 RH1 [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone], presently in late preclinical and entering early clinical development, has been previously considered to be an excellent substrate for activation by NQO1. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone NAD(P)H quinone dehydrogenase 1 Homo sapiens
2 RH1 [2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone], presently in late preclinical and entering early clinical development, has been previously considered to be an excellent substrate for activation by NQO1. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone NAD(P)H quinone dehydrogenase 1 Homo sapiens