Pub. Date : 2005 May 1
PMID : 15746169
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The vagus regulates histamine mobilization from rat stomach ECL cells by controlling their sensitivity to gastrin. | Histamine | gastrin | Rattus norvegicus |
| 2 | The ECL cells in the oxyntic mucosa secrete histamine in response to gastrin, stimulating parietal cells to produce acid. | Histamine | gastrin | Rattus norvegicus |
| 3 | The present study examines histamine mobilization from rat stomach ECL cells in situ in response to acute vagal excitation and to food or gastrin following vagal or sympathetic denervation. | Histamine | gastrin | Rattus norvegicus |
| 4 | However, gastrin receptor blockade prevented the histamine mobilization, indicating that circulating gastrin accounts for the response. | Histamine | gastrin | Rattus norvegicus |
| 5 | However, gastrin receptor blockade prevented the histamine mobilization, indicating that circulating gastrin accounts for the response. | Histamine | gastrin | Rattus norvegicus |
| 6 | The histamine response to food was almost abolished by gastrin receptor blockade, and it was halved on the denervated side after unilateral subdiaphragmatic vagotomy. | Histamine | gastrin | Rattus norvegicus |
| 7 | While the histamine response to a near-maximally effective dose of gastrin was unaffected by vagotomy, the response to low gastrin doses was reduced significantly. | Histamine | gastrin | Rattus norvegicus |
| 8 | In conclusion, gastrin is responsible for most of the food-evoked mobilization of ECL-cell histamine. | Histamine | gastrin | Rattus norvegicus |
| 9 | The histamine response to electrical vagal stimulation reflects the effect of circulating gastrin rather than a direct action of the vagus on the ECL cells. | Histamine | gastrin | Rattus norvegicus |
| 10 | Vagal denervation was accompanied by an impaired histamine response to food intake, probably reflecting the right-ward shift of the serum gastrin concentration-histamine response curve. | Histamine | gastrin | Rattus norvegicus |
| 11 | Vagal denervation was accompanied by an impaired histamine response to food intake, probably reflecting the right-ward shift of the serum gastrin concentration-histamine response curve. | Histamine | gastrin | Rattus norvegicus |