Title : Fluoxetine pretreatment potentiates intracisternal TRH analogue-stimulated gastric acid secretion in rats.

Pub. Date : 1992 Mar 19

PMID : 1574606






4 Functional Relationships(s)
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1 Accumulating evidence exists regarding the interaction of serotonin (5HT) with TRH containing neuronal systems. Serotonin thyrotropin releasing hormone Rattus norvegicus
2 Accumulating evidence exists regarding the interaction of serotonin (5HT) with TRH containing neuronal systems. Serotonin thyrotropin releasing hormone Rattus norvegicus
3 This study was performed to assess the effect of pretreatment with the 5HT uptake inhibitor fluoxetine on the TRH analogue-induced gastric acid secretory response. Serotonin thyrotropin releasing hormone Rattus norvegicus
4 The data suggest an interaction of synaptic serotonin with a RX 77368-elicited event (activation of TRH receptors, second messenger systems and/or firing of the motor vagus) results in potentiation of the RX 77368-induced gastric response. Serotonin thyrotropin releasing hormone Rattus norvegicus