Title : Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes.

Pub. Date : 2005 Feb 15

PMID : 15746066






1 Functional Relationships(s)
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1 Troleandomycin and ketoconazole, both inhibitors of CYP3A, markedly reduced PNU-159682 formation by HLMs; the reaction was also concentration-dependently inhibited by a monoclonal antibody to CYP3A4/5. Troleandomycin cytochrome P450 family 3 subfamily A member 4 Homo sapiens