Title : G alpha 12/13- and reactive oxygen species-dependent activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in rat neonatal cardiomyocytes.

Pub. Date : 2005 May 6

PMID : 15743761






2 Functional Relationships(s)
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Protein Name
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1 Among three MAPKs, c-Jun NH(2)-terminal kinase (JNK) and p38 MAPK required ROS production for activation, as an NADPH oxidase inhibitor, diphenyleneiodonium, inhibited the activation. diphenyleneiodonium mitogen activated protein kinase 14 Rattus norvegicus
2 Constitutively active Galpha(12)- or Galpha(13)-induced activation of JNK and p38 MAPK, but not extracellular signal-regulated kinase (ERK), was inhibited by diphenyleneiodonium. diphenyleneiodonium mitogen activated protein kinase 14 Rattus norvegicus