Title : Induction of apoptosis by the Anthocyanidins through regulation of Bcl-2 gene and activation of c-Jun N-terminal kinase cascade in hepatoma cells.

Pub. Date : 2005 Mar 9

PMID : 15740068






2 Functional Relationships(s)
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1 RT-PCR and Western blot data revealed that delphinidin stimulated an increase in the c-Jun and JNK phosphorylation expression at mRNA and protein levels, respectively. delphinidin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens
2 Our experiments provide evidence that delphinidin is an effective apoptosis inducer in HepG(2) cells through regulation of Bcl-2 family moleculars and activation of c-Jun N-terminal kinase cascade. delphinidin Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens