Pub. Date : 2005 Apr 7
PMID : 15735738
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. | gingerol | mitogen-activated protein kinase 14 | Mus musculus |
| 2 | Moreover, [6]-gingerol prevented TPA-induced phosphorylation and catalytic activity of p38 mitogen-activated protein (MAP) kinase that regulates COX-2 expression in mouse skin. | gingerol | mitogen-activated protein kinase 14 | Mus musculus |
| 3 | Taken together, our data suggest that [6]-gingerol inhibits TPA-induced COX-2 expression in mouse skin in vivo by blocking the p38 MAP kinase-NF-kappaB signaling pathway. | gingerol | mitogen-activated protein kinase 14 | Mus musculus |