Title : [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin.

Pub. Date : 2005 Apr 7

PMID : 15735738






2 Functional Relationships(s)
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1 Pretreatment with [6]-gingerol resulted in a decrease in both TPA-induced DNA binding and transcriptional activities of NF-kappaB through suppression of IkappaBalpha degradation and p65 nuclear translocation. Tetradecanoylphorbol Acetate v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
2 In addition, [6]-gingerol inhibited TPA-stimulated interaction of phospho-p65-(Ser-536) with cAMP response element binding protein-binding protein, a transcriptional coactivator of NF-kappaB. Tetradecanoylphorbol Acetate v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus