Title : Inhibition of human intestinal wall metabolism by macrolide antibiotics: effect of clarithromycin on cytochrome P450 3A4/5 activity and expression.

Pub. Date : 2005 Mar

PMID : 15735612






1 Functional Relationships(s)
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1 Intestinal CYP3A activity was determined from the rate of 1"-hydroxymidazolam and 4-hydroxymidazolam formation by incubation of small-bowel homogenate with midazolam (25 micromol/L) and NADPH for 5 minutes. 1-hydroxymethylmidazolam cytochrome P450 family 3 subfamily A member 4 Homo sapiens