Title : Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta.

Pub. Date : 2005 May

PMID : 15731493






2 Functional Relationships(s)
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1 METHODS AND RESULTS: We demonstrate that insulin-mediated tyrosine phosphorylation of IRS-1 and serine phosphorylation of Akt, eNOS, and NO production are significantly inhibited by treatment of bovine aortic endothelial cells with 100 micromol/L FFA composed of palmitic acid for 3 hours before stimulation with 100 nM insulin. Serine insulin Bos taurus
2 METHODS AND RESULTS: We demonstrate that insulin-mediated tyrosine phosphorylation of IRS-1 and serine phosphorylation of Akt, eNOS, and NO production are significantly inhibited by treatment of bovine aortic endothelial cells with 100 micromol/L FFA composed of palmitic acid for 3 hours before stimulation with 100 nM insulin. Serine insulin Bos taurus