Title : Amphetamine induces apoptosis of medium spiny striatal projection neurons via the mitochondria-dependent pathway.

Pub. Date : 2005 May

PMID : 15731293






1 Functional Relationships(s)
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1 Administration of a dose of the drug (10 mg/kg, 4 times, every 2 h) that is toxic to dopaminergic terminals resulted in the appearance of striatal cells that were positive for cleaved caspase-3 and for terminal deoxynucleotidyl transferase-mediated biotin-dUTP nick-end labeling (TUNEL), observations that are indicative of an ongoing apoptotic process. Biotin DNA nucleotidylexotransferase Homo sapiens