Title : Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4.

Pub. Date : 2005 Mar 1

PMID : 15728517






2 Functional Relationships(s)
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1 The induction of IRAK-M by hyaluronan and tumor cells was abolished by incubation with anti-CD44 or anti-TLR4 blocking Abs. Hyaluronic Acid toll like receptor 4 Homo sapiens
2 Altogether, our findings indicate that deactivation of human monocytes in the presence of tumor cells involves IRAK-M up-regulation, and this effect appears to be mediated by hyaluronan through the engagement of CD44 and TLR4. Hyaluronic Acid toll like receptor 4 Homo sapiens