Title : RAW264.7 cells lack prostaglandin-dependent autoregulation of tumor necrosis factor-alpha secretion.

Pub. Date : 2005 May

PMID : 15722559






2 Functional Relationships(s)
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1 This failure of endogenous PGs to suppress TNF-alpha secretion was explained by the absence of the prostaglandin D2 receptor and the low levels of PGE2 produced during the first 2 h of the LPS response. Phosphatidylglycerols tumor necrosis factor Mus musculus
2 These studies demonstrate that autocrine regulation of TNF-alpha secretion in response to LPS is greatly facilitated by a COX-1-mediated rapid accumulation of PGs as well by a correspondence between the PGs produced and the receptors expressed by the cells. Phosphatidylglycerols tumor necrosis factor Mus musculus