Title : Impact of remote mutations on metallo-beta-lactamase substrate specificity: implications for the evolution of antibiotic resistance.

Pub. Date : 2005 Mar

PMID : 15722450






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The G262S point mutation distinguishing the metallo-beta-lactamase IMP-1 from IMP-6 has no effect on the hydrolysis of the drugs cephalothin and cefotaxime, but significantly improves catalytic efficiency toward cephaloridine, ceftazidime, benzylpenicillin, ampicillin, and imipenem. Imipenem insulin like growth factor 2 mRNA binding protein 1 Homo sapiens