Title : Antifibrotic effect of adrenomedullin on coronary adventitia in angiotensin II-induced hypertensive rats.

Pub. Date : 2005 Mar 1

PMID : 15721873






1 Functional Relationships(s)
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1 In cultured cardiac fibroblasts, 10(-7) mol/L AM exerted an inhibitory effect on TGF-beta1-induced alpha-SMA expression (p<0.01) that was mimicked by 8-bromo-cAMP and attenuated by the protein kinase A inhibitor H-89. 8-Bromo Cyclic Adenosine Monophosphate transforming growth factor, beta 1 Rattus norvegicus