Title : Oxidized low-density lipoprotein increases superoxide production by endothelial nitric oxide synthase by inhibiting PKCalpha.

Pub. Date : 2005 Mar 1

PMID : 15721870






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 OBJECTIVE: Oxidized low-density lipoprotein (ox-LDL) increases superoxide anion (O(2)(-)) production by the endothelial nitric oxide (NO) synthase (eNOS). Superoxides nitric oxide synthase 3 Homo sapiens
2 OBJECTIVE: Oxidized low-density lipoprotein (ox-LDL) increases superoxide anion (O(2)(-)) production by the endothelial nitric oxide (NO) synthase (eNOS). Superoxides nitric oxide synthase 3 Homo sapiens
3 In COS-7 cells, a T495A eNOS mutant generated significantly more O(2)(-) than a T495D mutant did, indicating that the dephosphorylation of Thr(495) alone can increase O(2)(-) production by eNOS. Superoxides nitric oxide synthase 3 Homo sapiens
4 In COS-7 cells, a T495A eNOS mutant generated significantly more O(2)(-) than a T495D mutant did, indicating that the dephosphorylation of Thr(495) alone can increase O(2)(-) production by eNOS. Superoxides nitric oxide synthase 3 Homo sapiens