Title : Human adipose angiotensinogen gene expression and secretion are stimulated by cyclic AMP via increased DNA cyclic AMP responsive element binding activity.

Pub. Date : 2004 Nov

PMID : 15711021






2 Functional Relationships(s)
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1 A 24 h exposure to the cAMP analog 8Br-cAMP resulted in significant increases in ATG mRNA levels (+176+/-60%) and protein secretion (+40+/-27%). 8-Bromo Cyclic Adenosine Monophosphate angiotensinogen Homo sapiens
2 The ability of 8Br-cAMP to promote ATG gene expression was unaltered by H89, a protein kinase A inhibitor, because H89 per se was found to stimulate ATG mRNA levels and protein secretion. 8-Bromo Cyclic Adenosine Monophosphate angiotensinogen Homo sapiens