Title : Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy.

Pub. Date : 2005 Mar

PMID : 15707415






1 Functional Relationships(s)
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1 When treated with a SRL-based therapy and low-dose steroids, patients carrying the CYP3A4*1B or the CYP3A5*1 alleles required significantly more SRL to achieve adequate blood trough concentrations (p < 0.01 and p < 0.02, respectively). Steroids cytochrome P450 family 3 subfamily A member 4 Homo sapiens