Title : Escherichia coli FolC structure reveals an unexpected dihydrofolate binding site providing an attractive target for anti-microbial therapy.

Pub. Date : 2005 May 13

PMID : 15705579






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 FolC structure revealed an unexpected dihydropteroate binding site very different from the folate site identified previously in the FPGS structure. Folic Acid folylpolyglutamate synthase Homo sapiens
2 As such, the presence of a folate binding site in E. coli FolC, which is different from the one seen in FPGS enzymes, provides avenues for the design of specific inhibitors of this enzyme in antimicrobial therapy. Folic Acid folylpolyglutamate synthase Homo sapiens