Pub. Date : 2005 Apr 22
PMID : 15701627
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both wild-type and, in particular, repair-deficient DNA polymerase beta null cells are highly sensitized to the cytotoxic effects of MMS by 4-amino-1,8-naphthalimide (4-AN), an inhibitor of poly(ADP-ribose) polymerase (PARP) activity. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 2 | Both wild-type and, in particular, repair-deficient DNA polymerase beta null cells are highly sensitized to the cytotoxic effects of MMS by 4-amino-1,8-naphthalimide (4-AN), an inhibitor of poly(ADP-ribose) polymerase (PARP) activity. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 3 | In PARP-1-expressing fibroblasts treated with a combination of MMS and 4-AN, a complete inhibition of DNA synthesis is apparent after 4 h, and by 24 h, all cells are arrested in S-phase of the cell cycle. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 4 | Our results suggest that inhibition of PARP activity results in sensitization to MMS through maintenance of an ATR and Chk1-dependent S-phase checkpoint. | Methyl Methanesulfonate | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |