Title : Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis.

Pub. Date : 2005 Feb

PMID : 15696087






7 Functional Relationships(s)
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1 Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis. Aspirin cysteinyl leukotriene receptor 1 Homo sapiens
2 Expression of the cysteinyl leukotriene receptors cysLT(1) and cysLT(2) in aspirin-sensitive and aspirin-tolerant chronic rhinosinusitis. Aspirin cysteinyl leukotriene receptor 1 Homo sapiens
3 We previously compared expression of cysLT 1 on mucosal leukocytes in patients with aspirin-sensitive and aspirin-tolerant rhinosinusitis. Aspirin cysteinyl leukotriene receptor 1 Homo sapiens
4 We previously compared expression of cysLT 1 on mucosal leukocytes in patients with aspirin-sensitive and aspirin-tolerant rhinosinusitis. Aspirin cysteinyl leukotriene receptor 1 Homo sapiens
5 OBJECTIVE: To compare expression of cysLT 1 and cysLT 2 on leukocytes, mucus glands, and epithelium in 32 patients with chronic polypoid rhinosinusitis (21 aspirin-sensitive, 11 aspirin-tolerant) and 9 normal controls. Aspirin cysteinyl leukotriene receptor 1 Homo sapiens
6 RESULTS: The percentages of mucosal CD45 + leukocytes expressing cysLT 1 were significantly ( P < .0001) elevated in the aspirin-sensitive but not the aspirin-tolerant patients compared with the controls. Aspirin cysteinyl leukotriene receptor 1 Homo sapiens
7 CONCLUSION: Although cysLT 1 expression predominates on inflammatory leukocytes in patients with aspirin-sensitive rhinosinusitis, the effects of cysteinyl leukotrienes on glands and epithelium may be mediated predominantly through cysLT 2. Aspirin cysteinyl leukotriene receptor 1 Homo sapiens