Title : D-Glucose upregulates adenosine transport in cultured human aortic smooth muscle cells.

Pub. Date : 2005 Jun

PMID : 15695555






2 Functional Relationships(s)
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1 Although RT-PCR demonstrated the presence of equilibrative nucleoside transporter-1 (ENT-1) and ENT-2 mRNA, functional studies revealed that adenosine transport in HASMCs was predominantly mediated by ENT-1 and inhibited by nitrobenzylmercaptopurine riboside (NBMPR, IC(50) = 0.69 +/- 0.05 nM). Adenosine solute carrier family 29 member 1 (Augustine blood group) Homo sapiens
2 Pathologically, the increase in ENT-1 activity in diabetes may affect the availability of adenosine in the vicinity of adenosine receptors and, thus, alter vascular functions in diabetes. Adenosine solute carrier family 29 member 1 (Augustine blood group) Homo sapiens