Pub. Date : 2005 Jun 1
PMID : 15693753
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A 40% cholesterol depletion of DRM caused the loss of 52% of the P-gp ATPase activity. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Cholesterol repletion allowed recovery of the initial P-gp ATPase activity. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | In contrast, in the solubilized-membrane-containing fractions, cholesterol depletion and repletion had no effect on the P-gp ATPase activity whereas up to 100% saturation with cholesterol induced a 58% increased P-gp ATPase activity, while no significant modification was observed for the DRM-enriched fraction. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | DRMs were analysed by atomic force microscopy: 40-60% cholesterol depletion was necessary to remove P-gp from DRMs. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | In conclusion, P-gp in DRMs appears to contain closely surrounding cholesterol that can stimulate P-gp ATPase activity to its optimal value, whereas cholesterol in the second population seems deprived of this function. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | In conclusion, P-gp in DRMs appears to contain closely surrounding cholesterol that can stimulate P-gp ATPase activity to its optimal value, whereas cholesterol in the second population seems deprived of this function. | Cholesterol | ATP binding cassette subfamily B member 1 | Homo sapiens |