Title : Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway.

Pub. Date : 2005 Mar

PMID : 15692808






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1 In addition, we demonstrated that inhibition of the mTOR pathway with rapamycin can prevent insulin resistance caused by chronic hyperinsulinaemia in liver and muscle. Sirolimus mechanistic target of rapamycin kinase Rattus norvegicus