Title : Effect of specific and non-specific inhibition of COX-2 on renal oxygenation before and after water diuresis.

Pub. Date : 2005

PMID : 15692221






2 Functional Relationships(s)
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1 BACKGROUND/AIMS: Water diuresis usually increases medullary oxygenation as a result of increased medullary synthesis of prostaglandins, but it is not clear whether this involves activation of cyclooxygenase-1 (COX-1) or cyclooxygenase-2 (COX-2). Water mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 CONCLUSION: Renal medullary oxygenation is improved by water diuresis in normal young women in a way that is blocked by a selective inhibitor of COX-2 as well as non-selective cyclooxygenase inhibitors. Water mitochondrially encoded cytochrome c oxidase II Homo sapiens