Pub. Date : 2005 Feb 1
PMID : 15691529
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hypoxia activates glycogen synthase kinase-3 in mouse brain in vivo: protection by mood stabilizers and imipramine. | Imipramine | glycogen synthase kinase 3 beta | Mus musculus |
| 2 | METHODS: This study tested if the antidepressant imipramine or the mood stabilizers lithium and sodium valproate regulated pathophysiological serine-dephosphorylation of GSK3 caused by hypoxia in mouse brain in vivo. | Imipramine | glycogen synthase kinase 3 beta | Mus musculus |
| 3 | Pretreatment of mice with imipramine, sodium valproate, or lithium attenuated hypoxia-induced serine-dephosphorylation of GSK3beta and GSK3alpha in all three brain regions. | Imipramine | glycogen synthase kinase 3 beta | Mus musculus |
| 4 | CONCLUSIONS: These results demonstrate that imipramine and mood stabilizers are capable of blocking pathophysiologically induced serine-dephosphorylation of GSK3, supporting the hypothesis that stabilization of serine-phosphorylation of GSK3 contributes to their therapeutic effects. | Imipramine | glycogen synthase kinase 3 beta | Mus musculus |
| 5 | CONCLUSIONS: These results demonstrate that imipramine and mood stabilizers are capable of blocking pathophysiologically induced serine-dephosphorylation of GSK3, supporting the hypothesis that stabilization of serine-phosphorylation of GSK3 contributes to their therapeutic effects. | Imipramine | glycogen synthase kinase 3 beta | Mus musculus |