Title : Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats.

Pub. Date : 2004 Dec

PMID : 15684702






1 Functional Relationships(s)
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1 A single injection of rat PGIS cDNA-encoding plasmid into thigh muscle 3 days after bupivacaine pretreatment transiently increased muscle PGIS protein expression and muscle and serum levels of a stable prostacyclin metabolite (6-keto-prostaglandin F1). Epoprostenol prostaglandin I2 synthase Rattus norvegicus