Title : Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants.

Pub. Date : 2005 Feb

PMID : 15684493






1 Functional Relationships(s)
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1 Furthermore, oxatomide inhibited the metabolism of (+/-) bufuralol and testosterone, model substrates for CYP2D6 and CYP3A4, respectively, in a dose-dependent manner with the Ki values of 57.4 and 24.3 microM, respectively. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens