Title : NADPH-consuming enzymes correlate with glucose-6-phosphate dehydrogenase in Purkinje cells: an immunohistochemical and enzyme histochemical study of the rat cerebellar cortex.

Pub. Date : 2005 Feb

PMID : 15681036






4 Functional Relationships(s)
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1 NADPH-consuming enzymes correlate with glucose-6-phosphate dehydrogenase in Purkinje cells: an immunohistochemical and enzyme histochemical study of the rat cerebellar cortex. NADP glucose-6-phosphate dehydrogenase Rattus norvegicus
2 G6PD is the first and rate-limiting step of the hexose monophosphate shunt (HMS), which has the physiological role of providing NADPH for reductive biosynthesis and detoxifying reactions. NADP glucose-6-phosphate dehydrogenase Rattus norvegicus
3 In this study, we searched for a possible correlation between G6PD and other NADPH-consuming enzymes, such as NADPH-cytochrome P450 reductase (P450R), glutathione reductase (GR) and NADPH-diaphorase (NADPH-d). NADP glucose-6-phosphate dehydrogenase Rattus norvegicus
4 Our results suggest a coordinated regulative mechanism of G6PD, P450R and GR based on the request of NADPH or on specific transcription factors. NADP glucose-6-phosphate dehydrogenase Rattus norvegicus