Title : NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives.

Pub. Date : 2005 Jan 31

PMID : 15680249






1 Functional Relationships(s)
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1 We show that, in cytokine-treated synoviocytes (from non-rheumatic patients), NO-naproxen and NO-flurbiprofen like their parent compounds concentration-dependently reduce the levels of PGE2 (an index of COX-2 activity), with a corresponding rise in the release of GM-CSF. Flurbiprofen mitochondrially encoded cytochrome c oxidase II Homo sapiens