Title : TCDD causes suppression of growth and differentiation of MCF10A, human mammary epithelial cells by interfering with their insulin receptor signaling through c-Src kinase and ERK activation.

Pub. Date : 2004

PMID : 15674848






3 Functional Relationships(s)
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1 TCDD causes suppression of growth and differentiation of MCF10A, human mammary epithelial cells by interfering with their insulin receptor signaling through c-Src kinase and ERK activation. Polychlorinated Dibenzodioxins C-terminal Src kinase Homo sapiens
2 To test the hypothesis that TCDD-induced c-Src kinase activation is casually related to this compound"s antagonistic action against insulin, we treated MCF10A cells with two c-Src blocking agents, an anti-Src antisense oligonucleotides blocker and a known specific inhibitor of c-Src kinase, PP-2 and studied the effect of insulin and TCDD on cell proliferation. Polychlorinated Dibenzodioxins C-terminal Src kinase Homo sapiens
3 To test the hypothesis that TCDD-induced c-Src kinase activation is casually related to this compound"s antagonistic action against insulin, we treated MCF10A cells with two c-Src blocking agents, an anti-Src antisense oligonucleotides blocker and a known specific inhibitor of c-Src kinase, PP-2 and studied the effect of insulin and TCDD on cell proliferation. Polychlorinated Dibenzodioxins C-terminal Src kinase Homo sapiens