Pub. Date : 2005 Mar 17
PMID : 15674326
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hematopoietic cytokines enhance Chk1-dependent G2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | The G2/M arrest induced by etoposide was also enhanced or inhibited by expression of a constitutively activated or dominant-negative Akt mutant, respectively. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Furthermore, SB216763 or LiCl, a specific inhibitor for the GSK3 kinase inhibited by Akt, enhanced the Chk1 phosphorylation and G2/M arrest by etoposide. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | These results indicate that hematopoietic cytokines protect etoposide-treated cells from DNA damage-induced apoptosis by promoting, through the PI3K/Akt/GSK3 signaling pathway, G2/M checkpoint that is dependent on Chk1-mediated inhibition of Cdc2. | Etoposide | AKT serine/threonine kinase 1 | Homo sapiens |