Title : Retinol forms retinoic acid via retinal.

Pub. Date : 1992 May 1

PMID : 1567193






4 Functional Relationships(s)
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1 Hepatic cytosol from normal deermice having cytosolic alcohol dehydrogenase (ADH+) also displays retinol dehydrogenase activity and converts retinol to retinoic acid, whereas cytosol from ADH- deermice lacks these enzyme activities and does not produce retinoic acid. Vitamin A aldo-keto reductase family 1 member A1 Homo sapiens
2 Hepatic cytosol from normal deermice having cytosolic alcohol dehydrogenase (ADH+) also displays retinol dehydrogenase activity and converts retinol to retinoic acid, whereas cytosol from ADH- deermice lacks these enzyme activities and does not produce retinoic acid. Vitamin A aldo-keto reductase family 1 member A1 Homo sapiens
3 Microsomal retinol dehydrogenase also catalyzes the reduction of retinal to retinol, thereby explaining the decrease in retinoic acid production from retinol in liver cytosol of ADH+ deermice when microsomes are added. Vitamin A aldo-keto reductase family 1 member A1 Homo sapiens
4 Microsomal retinol dehydrogenase also catalyzes the reduction of retinal to retinol, thereby explaining the decrease in retinoic acid production from retinol in liver cytosol of ADH+ deermice when microsomes are added. Vitamin A aldo-keto reductase family 1 member A1 Homo sapiens