Title : Erythromycin exerts in vivo anti-inflammatory activity downregulating cell adhesion molecule expression.

Pub. Date : 2005 Jan

PMID : 15665859






1 Functional Relationships(s)
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1 Erythromycin pretreatment (30 mg kg(-1) day(-1) for 1 week) reduced the lipopolysaccharide (LPS; intratracheal, 0.4 mg kg(-1))-induced increase in neutrophil count and elastase activity in the bronchoalveolar lavage fluid (BALF) and lung tissue myeloperoxidase activity, but failed to decrease tumor necrosis factor-alpha and macrophage-inflammatory protein-2 augmented levels in BALF. Erythromycin tumor necrosis factor Rattus norvegicus