Title : 5-azacytidine induces cardiac differentiation of P19 embryonic stem cells.

Pub. Date : 2004 Dec 31

PMID : 15665584






1 Functional Relationships(s)
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1 In response to 1 mM of 5-aza, P19 cells expressed bone morphogenetic protein-2 (BMP-2), BMP-4, Bmpr1a and Smad1 at day 6 or 9, and also cardiac markers such as GATA-4, Nkx2.5, cardiac troponin I, and desmin were up-regulated in a time-dependent manner after induction of BMP signaling molecules. Azacitidine NK2 homeobox 5 Homo sapiens