Title : BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes.

Pub. Date : 2005 Feb 1

PMID : 15665077






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 It was found that exposure to the neurotrophin BDNF increased the amplitude of the "GABA currents" (currents elicited by GABA) generated by the epileptic receptors and decreased their run-down; both events being blocked by K252A, a neurotrophin tyrosine kinase receptor B inhibitor. gamma-Aminobutyric Acid brain derived neurotrophic factor Homo sapiens
2 It was found that exposure to the neurotrophin BDNF increased the amplitude of the "GABA currents" (currents elicited by GABA) generated by the epileptic receptors and decreased their run-down; both events being blocked by K252A, a neurotrophin tyrosine kinase receptor B inhibitor. gamma-Aminobutyric Acid brain derived neurotrophic factor Homo sapiens
3 However, staurosporine (a broad spectrum PK inhibitor), bisindolylmaleimide I (a PKC inhibitor), and U73122 (a phospholipase C inhibitor) blocked the BDNF-induced effects on the epileptic GABA currents. gamma-Aminobutyric Acid brain derived neurotrophic factor Homo sapiens