Pub. Date : 2005 Feb
PMID : 15663890
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Caspase-1 inhibitor Ac-YVAD-CHO attenuates quinolinic acid-induced increases in p53 and apoptosis in rat striatum. | Quinolinic Acid | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 2 | The effects of Ac-YVAD-CHO on QA-induced caspase-1 activity, internucleosomal DNA fragmentation, IkappaB-alpha degradation, NF-kappaB, and AP-1 activation, and increases in p53 protein levels were measured with enzyme assays, agarose gel electrophoresis, electrophoresis mobility shift assays, and Western blot analysis. | Quinolinic Acid | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 3 | Ac-YVAD-CHO inhibited QA-induced increases in caspase-1 activity and p53 protein levels, but had no effect on QA-induced IkappaB-alpha degradation, NF-kappaB or AP-1 activation. | Quinolinic Acid | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |
| 4 | CONCLUSION: Caspase-1 is involved in QA-induced p53 upregulation but not IkappaB-alpha degradation. | Quinolinic Acid | Wistar clone pR53P1 p53 pseudogene | Rattus norvegicus |