Title : Cooperative effects between protein kinase A and p44/p42 mitogen-activated protein kinase to promote cAMP-responsive element binding protein activation after beta cell stimulation by glucose and its alteration due to glucotoxicity.

Pub. Date : 2004 Dec

PMID : 15659802






1 Functional Relationships(s)
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1 The observation that glucose-induced CREB phosphorylation was totally inhibited by the PKA inhibitor H89 (2 microM) and reduced by 50% with the ERK1/2 inhibitor PD98059 (20 microM) indicates that ERK1/2, located downstream of PKA, cooperates with PKA and is responsible for half of the PKA-mediated CREB phosphorylation elicited by glucose in MIN6 beta cells. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one cAMP responsive element binding protein 1 Mus musculus