Title : Cooperative effects between protein kinase A and p44/p42 mitogen-activated protein kinase to promote cAMP-responsive element binding protein activation after beta cell stimulation by glucose and its alteration due to glucotoxicity.

Pub. Date : 2004 Dec

PMID : 15659802






1 Functional Relationships(s)
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1 We report that glucose (10 mM) induces an increase in cytosolic calcium concentration that leads to cAMP-induced protein kinase A (PKA) activation, promoting nuclear translocation of activated ERK1/2. Cyclic AMP mitogen-activated protein kinase 3 Mus musculus