Title : Randomized pharmacokinetic and pharmacodynamic study of docetaxel: dosing based on body-surface area compared with individualized dosing based on cytochrome P450 activity estimated using a urinary metabolite of exogenous cortisol.

Pub. Date : 2005 Feb 20

PMID : 15657405






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1 We developed a novel method for estimating the interpatient variability of CYP3A4 activity by the urinary metabolite of exogenous cortisol (6-beta-hydroxycortisol [6-beta-OHF]). 6 beta-hydroxycortisol cytochrome P450 family 3 subfamily A member 4 Homo sapiens