Pub. Date : 2005 Jun
PMID : 15654584
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD. | Methionine | catechol-O-methyltransferase | Homo sapiens |
| 2 | COMT genotype, however, affected prefrontal cognition in ADHD: ADHD children who were homozygous for the valine variant had significantly better sustained attention than those ADHD children possessing at least one copy of the methionine variant. | Methionine | catechol-O-methyltransferase | Homo sapiens |
| 3 | Contrary to expectations, the methionine variant of the Val158Met COMT gene polymorphism impaired prefrontally-mediated cognition in ADHD. | Methionine | catechol-O-methyltransferase | Homo sapiens |
| 4 | Against this background, the slower clearance of dopamine associated with the methionine variant of the COMT gene polymorphism may be disadvantageous to cognition in ADHD. | Methionine | catechol-O-methyltransferase | Homo sapiens |