Title : GABA(A) receptor facilitation of neurokinin release from primary afferent terminals in the rat spinal cord.

Pub. Date : 2005

PMID : 15652997






1 Functional Relationships(s)
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1 The GABA(B) agonist baclofen inhibited NK1R internalization evoked by 100 Hz root stimulation (IC50 1.5 microM), whereas the GABA(B) receptor antagonist (2S)-3-[[(1S)-1-(3,4-dichlorophenyl)ethyl]amino-2-hydroxypropyl](phenylmethyl) phosphinic acid (CGP-55845) increased NK1R internalization evoked by 1 Hz root stimulation (EC50 21 nM). gamma-Aminobutyric Acid tachykinin receptor 1 Rattus norvegicus